Chuang et al ​[1]​ reported that MS5 (the mid-sagittal line between Baihui (DU20) and Qianding (DU21)), the left MS6 (line joining Sishencong (EX-HN1) and Xuanli (GB6)), and the left MS7 (line joining DU20 and Qubin (GB7)) could cause changes in the fractional amplitude of low frequency fluctuations and regional homogeneity in various areas, showing remarkable enhancement of regional homogeneity in the bilateral anterior cingulate, left medial frontal gyrus, supramarginal gyrus, right middle frontal gyrus, and inferior frontal gyrus. They concluded that WHO standard scalp acupuncture in healthy elderly participants specifcally enhanced the correlation between the brain regions involved in cognition and implementation of the brain network regulation system and the surrounding adjacent brain regions.

  1. 1.
    Chen J-Q, Wang S-X, Chung W-Y, Liu S-Y, Gao J-C, Jiang Y-J, et al. Modulatory effect of International Standard Scalp Acupuncture on brain activation in the elderly as revealed by resting-state fMRI. Neural Regen Res [Internet]. 2019;2126. Available from: