Liew TM​(Liew 2019)​ from National University of Singapore reported a review based on cohort study. At baseline, 1307 participants (9.7%) had depression and 3582 (26.6%) had subjective cognitive decline (SCD). During follow-up, 1490 (11.1%) developed MCI/dementia. Depression and SCD demonstrated independent risks of MCI/dementia (HR 1.4 and 2.0 respectively). The risk was highest when depression and SCD co-occur (HR 2.8), with half of the participants in this group developing MCI/dementia within 7.2 years of follow-up (compared to 12.2 years in participants without depression or SCD). Therefore, the author concluded that the clinical approach in managing SCD in depression might be changed and greater emphasis on detecting prodromal neurocognitive disorders were needed. Further research to delineate the commonalities and distinctions in the neurobiological pathways of depression and SCD were required.

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  1. Liew, Tau Ming. 2019. “Depression, Subjective Cognitive Decline, and the Risk of Neurocognitive Disorders.” Alzheimer’s Research & Therapy, August. https://doi.org/10.1186/s13195-019-0527-7.