Lee et al ​1​ compared 135 patients with obstructive sleep apnea (OSA) with 165 healthy controls using fractional anisotropy (FA) analysis to document differences in brain network connectivity as a biomarker of cognitive deficits and brain tissue dysfunction. The study found that differences in the cingulate area and amygdala and lower FA values in the white matter (WM) of the right transverse temporal, anterior cingulate, and paracingulate gyri, of the left postcentral, middle frontal, and medial frontal gyri, and of the putamen in the OSA group. Therefore, the authors concluded that changes in WM integrity and structural connectivity are present in patients with OSA.

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  1. 1.
    Lee M-H, Yun C-H, Min A, Hwang YH, Lee SK, Kim DY, et al. Altered structural brain network resulting from white matter injury in obstructive sleep apnea. Sleep [Internet]. 2019 Jul 1; Available from: http://dx.doi.org/10.1093/sleep/zsz120