Chailingtang i.e. Xiao Chai Hu Tang （小柴胡汤） and Wu Ling San （五苓散） come from Shang Han Za Bing Lun and are frequently used to treat the coexistence of Taiyang exterior symptoms and internal damp symptoms in the digestion system. A research team from Tianjin University of Traditional Chinese Medicine and Shandong University carried out network pharmacology analysis and found 106 active components and 160 targets of the Chailingtang. Chailingtang might alleviate the inflammatory response and improve lung injury to treat COVID-19 through interleukin 17 signaling, T helper cell 17 differentiation, tumor necrosis factor signaling, and hypoxia inducible factor-1 signaling. Besides, molecular docking indicated that beta-sitosterol, kaempferol, and stigmasterol were the top three candidates in CLD with the highest affinity to SARS-CoV-2 and ACE2.
Lu Yang, Yu-Ting Li, Jing Miao, Li Wang, Hui Fu, Qin Li, Wei-Bo Wen, Zhai-Yi Zhang, Rui-Wen Song, Xiang-Guo Liu, Hong-Wu Wang, Huan-Tian Cui. Network pharmacology studies on the effect of Chai-Ling decoction in coronavirus disease 2019. Traditional Medicine Research, Online.