Ye et al  performed a systematic review and meta-analysis to evaluate the efficacy of acupuncture on anxiety and/or depression relief during IVF treatment. By analyzing 2867 participants, a significant difference (3 studies, 547 participants, MD -9.26, 95%CI −12.01 to -6.51, P<0.01) was observed in anxiety relief between acupuncture and control groups during IVF treatment. However, no significant difference (9 studies, 1896 participants, RR=1.30, 95%CI 1.03 to 1.64; P=0.02) was found for clinical pregnancy rate. Only 2 of 12 studies assessed remission of depression and showed inconsistent effects on depression relief of acupuncture. Based on the above findings, they concluded that acupuncture may have a positive effect on anxiety relief during IVF treatment, while the effect on depression relief is inconclusive.
Ye J, He M, Qu F. Effects of Acupuncture on the Relief of Anxiety and/or Depression during In Vitro Fertilization: A Systematic Review and Meta-Analysis. Eur J Integrat Med, 2021, pre-proof, https://doi.org/10.1016/j.eujim.2021.101287